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KMID : 0438219730100010379
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Korea University Medical Journal
1973 Volume.10 No. 1 p.379 ~ p.391
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Effects of Vitamin E on the Elastic Fibers of Skin, Aorta and Lung in the Mouse by Histometrical Method
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Abstract
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The morphological changes that follow vitamin E administration and a state of vitamin E deficiency in the mouse were studied. Focus of attention was specially directed towards the changes on a histometrical basis of the elastic fibers of the skin, aorta and lung.
The results of the studies are summarized as follows :
1. The result indicated that vitamin E has influence on the skin up to a certain degree. The injection of vitamin E caused an increase of the epidermal thickness, while a vitamin E deficiency resulted in an opposite reaction-thinning.
2. In regards to the derma, vitamin E administration resulted in no changes, while a deficiency caused positive thinning.
3. The distribution of the elastic fibers in the derma after giving vitamin E showed an increase. On the other hand, a deficiency caused no significant difference in compared with normal control in the distribution of a given unit area. However, considering the dermal thinning that occurs after a deficiency, it was not surprising to observe a consequential decrease in the amount of elastic fibers in the derma.
4. Concerning the aorta, vitamin E deficiency resulted in an increase of thickness of the media but no observable changes in the number of elastic layers.
5. Changes noted in the general features of the aorta after vitamin E administration were hypertrophy and a dense arrangement of the elastic fibers. An irregular sparse arrangement with a variation of partly thickened and partly thinned areas of the elastic lamina was observed in the deficient groups.
6. Attention to the lungs revealed a slight increase in the distribution of elastic fibers in a given unit area after injection. A deficiency showed an emphysematous or interalveolar cell infiltration in some cases, and no significant difference was observed in the number of elastic fibers.
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